Indiana (24-3, 12-2 Big Ten) broke a first-place tie in the conference.
The Hoosiers had lost 17 consecutive games –since 1991–on the road against the Spartans.
NO. 2 MIAMI 54, VIRGINIA 50
In Coral Gables, Fla., Reggie Johnson made a tie-breaking layup with 5.7 seconds left, and Miami overcame a ragged offensive performance for the second game in a row to beat Virginia and remain unbeaten in the Atlantic Coast Conference.
MISSOURI 63, NO. 5 FLORIDA 60
In Columbia, Mo., Laurence Bowers posted a double-double with 17 points and 10 rebounds as Missouri shocked Florida.
NO. 15 BUTLER 68, DUQUESNE 49
In Indianapolis, Rotnei Clarke scored 16 points to lead Butler past Duquesne.
NO. 17 MARQUETTE 67, SETON HALL 46
In Newark, N.J., Vander Blue scored 19 points and Marquette used a sizeable rebounding advantage to beat Seton Hall.
NORTH CAROLINA 70, GEORGIA TECH 58
In Atlanta, James Michael McAdoo scored 22 points and grabbed 11 rebounds to end a three-game scoring slump and North Carolina took control with a 12-0 second-half run to beat Georgia Tech.
McAdoo scored in double figures in 21 of the first 22 games for North Carolina.
Marcus Georges-Hunt and Chris Bolden scored 12 points apiece for Georgia Tech.
TENNESSEE 82, LOUISIANA STATE 72
In Knoxville, Tenn., Jordan McRae scored a career-high 34 points and led Tennessee past Louisiana State University.
NORTH CAROLINA STATE 84, FLORIDA STATE 66
In Raleigh, N.C., freshman T.J. Warren had season-highs of 31 points and 13 rebounds to help North Carolina State beat Florida State.
BOSTON COLLEGE 69, MARYLAND 58
In Chestnut Hill, Mass., Olivier Hanlan scored 26 points and Boston College upended Maryland.
NO. 18 DELAWARE 69, GEORGE MASON 55
In Fairfax, Va., Elena Delle Donne scored 31 points, leading Delaware past George Mason.
NO. 21 SYRACUSE 58, RUTGERS 45
In Syracuse, N.Y., Syracuse beat Rutgers, denying Scarlet Knights coach C. Vivian Stringer her 900th victory.