Markel Starks hit a go-ahead 3-pointer with 5:35 left and made five free throws in final minute, helping the Hoyas (19-4, 9-3) remain atop the Big East.
Starks finished with 17 points. Freshman D’Vauntes Smith-Rivera added 14.
Cincinnati (19-7, 7-6) has lost three of its past four games.
NO. 6 CALIFORNIA 79, NO. 15 UCLA 51
In Los Angeles, Gennifer Brandon scored 16 points to lead a balanced offense as California (22-2, 12-1 Pac-12) beat UCLA (19-5, 10-3), handing the Bruins their first home loss of the season.
Brittany Boyd and Layshia Clarendon had 14 points each to lead the Bears to their 10th consecutive win.
NO. 21 COLORADO 55, ARIZONA 42
In Tucson, Ariz., Jen Reese scored 15 points to lead Colorado (19-5, 8-5 Pac-12) over Arizona (11-13, 3-10) for its fourth consecutive victory.