Russ Smith had a chance to tie it, but his 3-point attempt missed before Notre Dame students flooded the court to celebrate. It marked the sixth time in the last eight meetings that a game between the Fighting Irish (19-5, 7-6 Big East) and the Cardinals (19-5, 7-4) went into overtime.
Both teams missed crucial free throws in the final minute. Atkins missed two with 37 seconds left and Montrezi Harrell did the same for Louisville with 24 seconds to go.
The lead changed hands 26 times and the score was tied 16 times.
Jerian Grant, who fouled out with 1:57 left in the first overtime, led the Irish with 19 points. Garrick Sherman, getting more minutes after Jack Cooley and Tom Knight fouled out, added 17 points on 7 of 10 shooting as the Notre Dame bench outscored Louisville's 39-31.
Pat Connaughton had 16 points and 14 rebounds, Atkins added 14 points, and Cooley, who fouled out with 6:54 left in regulation, finished with 11 points and 11 rebounds.
Chane Behanan led Louisville with 30 points and 15 rebounds. Luke Hancock added 22 points, Smith had 21 points and 10 rebounds, and Gorgui Dieng had 17 points and 13 rebounds.
Both teams needed big shots to force the extra periods. In the fourth overtime, Atkins and Zach Auguste missed shots for the Irish, but Sherman tipped in the rebound to tie the score at 93 with 5 seconds left. Russ Smith had a last-second shot for the Cardinals but missed.
In the third overtime, Behanan scored inside with 16 seconds to go to tie it at 83. With 16 seconds left in the second overtime, Cameron Biedscheid hit a 3-pointer to force another period.
Both teams missed chances to win in the first overtime. Behanan blocked a shot inside by Notre Dame's Eric Atkins with 15 seconds left before Smith missed from 3-point range in the closing seconds for the Cardinals.
It didn't look as if the Cardinals were going to need overtime when Behanan made a free throw with 51 seconds left in regulation to make it 56-48. But Grant led the Irish on a 12-4 comeback, hitting three consecutive 3-pointers and then tying it on a three-point play with 16 seconds left. The Cardinals had a chance to win, but they never got a shot off as Siva lost control of the ball under the basket in the closing seconds.
WISCONSIN 65, No. 3 MICHIGAN 62
In Madison, Wis., Ben Brust hit a shot from just inside midcourt to tie the game at the end of regulation and added a tie-breaking 3-pointer with less than 40 seconds left in overtime as Wisconsin beat Michigan 65-62.
Brust scored 14 points for the Badgers (17-7, 8-3 Big Ten), while Jared Berggren added 13.
Trey Burke scored 19 points for Michigan (21-3, 8-3), while Tim Hardaway Jr. added 18.
The Wolverines became the third top three to lose this week as No. 1 Indiana lost to Illinois and No. 2 Florida was beaten by Arkansas.
OKLAHOMA 72, NO. 5 KANSAS 66
In Norman, Okla, Romero Osby scored 17 points, Steven Pledger added 15 and Oklahoma (15-7, 6-4 Big 12) held off Kansas (19-4, 7-3) to give the Jayhawks their first three-game losing streak in eight years.
The Sooners snapped a 10-game losing streak in the series.
NO. 6 GONZAGA 74, LOYOLA MARYMOUNT 55
In Spokane, Wash., Kevin Pangos and Kelly Olynyk each scored 20 points as Gonzaga (23-2, 10-0 West Coast) beat Loyola Marymount (8-16, 1-10), a victory which has the Bulldogs poised to break into the top 5.
NO. 12 MICHIGAN STATE 78, PURDUE 65
In West Lafayette, Ind., Branden Dawson scored 20 points and Keith Appling added 17, leading Michigan State (20-4, 9-2 Big Ten) past Purdue (12-12, 5-6).
The Spartans have won nine of their past 10 games and will have at least a share of the league lead regardless of what happens today when No. 1 Indiana visits No. 10 Ohio State.
NO. 13 KANSAS STATE 79, IOWA STATE 70
In Manhattan, Kan., Rodney McGruder scored 22 points and Angel Rodriguez added 20 as Kansas State (19-4, 8-2) knocked off Iowa State (16-7, 6-4) to take sole possession of first place in the Big 12.
NO. 14 BUTLER 59, GEORGE WASHINGTON 56
In Washington, Butler (20-4, 7-2 Atlantic 10) nearly blew a 17-point lead, going the last 7½ minutes without a field goal, before holding on against George Washington (11-11, 5-4).
Rotnei Clark scored 14 points and Roosevelt Jones had 12 for the Bulldogs, who broke a two-game road losing streak during their inaugural tour of unfamiliar hostile environments in the school’s first season in the Atlantic 10.
UNLV 64, NO. 15 NEW MEXICO 55
In Las Vegas, Anthony Bennett had 17 points and 12 rebounds to lead the UNLV (18-6, 5-4 Mountain West) over New Mexico (20-4, 7-2).
NO. 23 PITTSBURGH 62, NO. 17 CINCINNATI 52
In Cincinnati, Tray Woodall scored 14 points and led a late surge that sent Pittsburgh (20-5, 8-4) past Cincinnati (18-6, 6-5), keeping the momentum going for one of the Big East’s hottest teams.
The Panthers have won seven of their past eight games.
NO. 19 OREGON 73, UTAH 64
In Eugene, Ore., E.J. Singler had 21 points and Oregon (19-5, 8-3 Pac-12) overcame a poor start to end its three-game losing streak with a victory over Utah (10-13, 2-9).
NO. 20 GEORGETOWN 69, RUTGERS 63
In Piscataway, N.J., Markel Starks scored 20 points and Otto Porter took over down the stretch as Georgetown (17-4, 7-3 Big East) defeated Rutgers (12-10, 3-8).
Porter had 15 of his 19 points in the second half and grabbed 14 rebounds for the Hoyas, who have won five in a row and seven of their past eight.
NO. 22 OKLAHOMA STATE 72, TEXAS 59
In Austin, Texas, Marcus Smart scored 23 points and Oklahoma State (17-5, 7-3 Big 12) cruised past struggling Texas (10-13, 2-8), the Cowboys’ fifth consecutive win.
Markel Brown added 17 points for the Cowboys, who sputtered offensively for long stretches but used their own tough defense to clamp down on the Longhorns.
NO. 24 MARQUETTE 89, DEPAUL 78
In Milwaukee, Vander Blue scored 18 points and Junior Cadougan added 17 as Marquette (17-5, 8-2 Big East) held off DePaul, (10-13, 1-9) sending the Blue Demons to their eighth consecutive loss.
With the win, Marquette moved one-half game ahead of No. 9 Syracuse for first place in the Big East. Syracuse plays at home today against St. Johns.