The lopsided outcome was somewhat surprising considering what was at stake for both teams in the Big East.
Marquette had an opportunity to take a one-game lead on Syracuse, but the Golden Eagles were left settling for a first-place tie with the Orange.
The Cardinals (18-4, 6-3), meanwhile, moved a half-game closer to both schools with their second consecutive win, remaining in a four-way tie for third.
The Cardinals finished 27 of 52 from the field after an 0 for 8 start while holding the Golden Eagles (15-5, 6-2) to 36 percent shooting (19 of 53). They also outrebounded Marquette 38-26.
Gorgui Dieng added eight points and eight rebounds for Louisville.
Vander Blue scored 17 points and Trent Lockett chipped in with 16 for the Golden Eagles, who have dropped two of their past four games.
NO. 23 MINNESOTA 62, IOWA 59
In Minneapolis, Austin Hollins hit a go-ahead 3-pointer with 11.6 seconds left, lifting Minnesota to a victory over Iowa.
Hollins finished with 17 points to help the Gophers (17-5, 5-4 Big Ten) survive a rough second half and escape the scrappy Hawkeyes (14-8, 3-6).
With Minnesota trailing 59-57, the 6-foot-4 Hollins came off a screen to get open in the corner on an inbounds play and made the shot over 6-foot-1 Mike Gesell. Hollins then hounded Gesell in the corner on the other end to force the ball out of bounds.
Andre Hollins, who had 15 points, made two free throws to stretch the lead to three, and Gesell’s tying attempt rolled off the front rim. Gesell finished with 11 points, and Aaron White and Zach McCabe each had 10 for the Hawkeyes.
Before Gesell’s miss at the buzzer, the Hawkeyes turned the ball over on three straight possessions. Junior Roy Devyn Marble went scoreless for Iowa for the first time since his freshman year.
Joe Coleman had 12 points for Minnesota. Rodney Williams added 10 points and had two of the team’s seven blocked shots.