The Hurricanes (14-3, 5-0 Atlantic Coast Conference) beat a No. 1 team for the first time, taking control with a stunning 25-1 run midway through the first half.
The Blue Devils missed 13 consecutive shots despite numerous good looks, while four Hurricanes hit 3-pointers during the stunning run that transformed a 14-13 deficit into a 38-15 lead.
Duke (16-2, 3-2) fell to 0-2 when playing on an opponent’s court. The Blue Devils’ other loss came at North Carolina State, a defeat cost them the No. 1 ranking.
It was third-worst loss ever for a No. a team.
NO. 7 INDIANA 72, PENN STATE 49
In Bloomington, Ind., Victor Oladipo scored 19 points, and Yogi Ferrell added a season-high 15 to help Indiana (17-2, 5-1 Big Ten) rout Penn State (8-11, 0-7).
The Hoosiers survived a sluggish shooting first half with strong defense and used a fast second-half start to reassert their dominance in this series that has included only two home losses for Indiana.
Will Sheehey added 12 points for the Hoosiers, who matched a season-high by making 11 3-pointers in a game.
NO. 8 FLORIDA 64, GEORGIA 47
In Athens, Ga., Florida shook off a sluggish first half and romped past another Southeastern Conference opponent, beating Georgia behind 17 points from Scottie Wilbekin.
Florida (15-2, 5-0) trailed 27-24 at halftime, making just 1 of 9 attempts beyond the 3-point arc. But the Gators quickly turned things around after the break. Wilbeken and Mike Rosario hit back-to-back treys and forced Georgia into three consecutive turnovers.
The Gators led the rest of way, holding Georgia (7-11, 1-4) to only one field goal in the first 11½ minutes of the second half.
The Gators have won their first five SEC games by an average of nearly 25 points.
LA SALLE 54, NO. 9 BUTLER 53
In Philadelphia, Ramon Galloway went the length of the court for the winning basket with 2.7 seconds left to send La Salle (13-5, 3-2 Atlantic 10) to a victory over Butler (16-3, 3-1).
La Salle hadn’t defeated a top 10 team since 1980.
Butler’s leading scorer Rotnei Clarke missed his third consecutive game with a severely sprained neck.
NO. 12 MINNESOTA 48
In Evanston, Ill., Jared Swopshire had a game-high 16 points and Northwestern (12-8, 3-4 Big Ten) upset Minnesota 15-4, 3-3).
Trevor Mbakwe had 14 points and 16 rebounds for the Golden Gophers, who have lost three in a row.
NO. 15 NEW MEXICO 66,
COLORADO STATE 61
In Albuquerque, N.M., Tony Snell scored 23 points and New Mexico (17-2, 4-0 Mountain West) held off a late rally by Colorado State (15-4, 2-2).
Wes Eikmeier led the Rams with 20 points.
NO. 16 OREGON 68,
WASHINGTON STATE 61
In Eugene, Ore., E.J. Singler scored 19 points as Oregon (17-2, 6-0 Pac-12) rallied past Washington State (10-9, 1-5).
Mike Ladd had 19 points for the Cougars, who led by 10 at halftime.
DRAKE 74, NO. 17 CREIGHTON 69
In Des Moine, Iowa, Richard Carter scored 20 points and Drake (9-10, 3-5 Missouri Valley Conference), stunned Creighton (17-3, 6-2) .
Ben Simons added 13 for the Bulldogs who blew a 16-point lead before rallying for their first win over a ranked opponent in five years.
NO. 20 WICHITA STATE 62,
MISSOURI STATE 52
In Springfield, Mo., Cleanthony Early scored 17 points, Carl Hall added 15 and Wichita State (18-2, 7-1 Missouri Valley Conference) rallied for a victory over Missouri State (5-15, 3-5).
NORTH CAROLINA 79,
GEORGIA TECH 63
In Chapel Hill, N.C., Reggie Bullock scored 17 points and North Carolina beat Georgia Tech its third consecutive win.
P.J. Hairston had 15 points and James Michael McAdoo added 14 for the Tar Heels (13-5, 3-2 Atlantic Coast Conference).
Kammeon Holsey had 10 of his 18 points in the first half, but the Yellow Jackets (10-7, 0-5) had 19 turnovers and lost their fifth straight to remain the only team winless in ACC play.
LOUISIANA STATE 58,
TEXAS A&M 54
In Baton Rouge, La., Anthony Hickey scored 10 points and grabbed eight steals, as Louisiana State head coach Johnny Jones picked up his first Southeastern Conference win by beating Texas A&M.
The Tigers (10-6, 1-4) attempted 19 more shots than the Aggies (12-6, 2-3) but led for less than 10 minutes.
MISSISSIPPI STATE 70
In Fayetteville, Ark., Marshawn Powell scored 17 points as Arkansas (12-6, 3-2 SEC) continued its home dominance with a win over Mississippi State (7-10, 2-3) .
VANDERBILT 73, AUBURN 61
In Nashville, Tenn., Kedren Johnson scored 15 points to lead Vanderbilt (8-9, 2-3 SEC) over Auburn (8-10, 2-3).