Natalie Achonwa had 20 points and Jewell Loyd finished with 18 points and 13 rebounds for the Fighting Irish (13-1, 2-0 Big East) in their first game since handing then-No. 1 Connecticut its first loss of the season.
Kayla McBride was limited to 12 points on 4 for 14 shooting.
However, McBride keyed a second half surge that helped Notre Dame take its first lead since early in the game.
NO. 15 LOUISVILLE 66, RUTGERS 57 (OT)
In Louisville, Ky., Antonita Slaughter drained a 3-pointer to open overtime and finished the extra frame with six of her 10 points as Louisville (13-3, 1-1) earned its first Big East Conference win, topping Rutgers (9-6, 0-2).
Shoni Schimmel set a season-high for the second straight game with 21 points, none bigger than a jumper with 6 seconds left in regulation to force a 52-all tie that carried into overtime.
Slaughter hit her 3-pointer 13 seconds into overtime, and Sara Hammond followed with a trey about a minute later for a 58-52 lead.
Monique Reid added 18 points for Louisville (13-3).
NO. 21 OKLAHOMA STATE 76, NO. 17 KANSAS 59
In Stillwater, Okla., Liz Donohoe scored 24 points and Oklahoma State bounced back from defeats in its first two Big 12 games, beating Kansast.
Toni Young had 15 points for the Cowgirls (12-2, 1-2), who dropped their first two games of the season to conference rivals Texas Tech and No. 1 Baylor.
Brittney Martin had 14 points and 10 rebounds for Oklahoma State, and Tiffany Bias also had 14 points. The Cowgirls never trailed against the Jayhawks.
Carolyn Davis led No. 17 Kansas (11-3, 2-1) with 14 points.
Angel Goodrich had 12 points and eight assists.