Ryan Kelly added 12 points in the first half but sat out the second with what team officials said was a right leg injury.
The Blue Devils (15-0, 2-0 Atlantic Coast Conference) shot 48 percent, built a 42-31 rebounding advantage and pulled away down the stretch to improve to 58-4 at home against the Tigers.
Devin Booker had 12 points and 15 rebounds for Clemson (8-6, 0-2), which had season lows for points and shooting percentage (28 percent) and shot 12 percent in its brutal first half.
The Tigers had just 10 points at halftime, their fewest since scoring nine against Wake Forest in 2001.
NO. 10 MISSOURI 84, ALABAMA 68
In Columbia, Mo., Jabari Brown hit a career-high five consecutive 3-pointers after an early miss and Phil Pressey responded from a shaky first half with 11 points and 13 assists, leading Missouri to a victory over Alabama in its SEC debut Tuesday night.
Trevor Releford had a career-best 26 points with three 3-pointers and topped 1,000 points for Alabama (8-6, 0-1), which has lost six of eight. Coach Anthony Grant lost for the first time in seven career conference openers, three at VCU and four at Alabama.
Earnest Ross added a season-best 19 points for Missouri (12-2, 1-0).
NO. 13 CREIGHTON 91, DRAKE 61
In Omaha, Neb., Ethan Wragge matched career highs with 22 points and six 3-pointers for Creighton, which got off to a blistering start.
Doug McDermott added 16 points, Jahenns Manigat had 13 and Grant Gibbs 10 for the Bluejays (15-1, 4-0 Missouri Valley Conference), who won their ninth in a row.
Creighton has won 71 straight against opponents .500 or worse, and it was apparent early that the streak was in no jeopardy. The Bluejays made a season-high 16 3-pointers.
Joey King scored 17 points for Drake (6-9, 0-4).
Wragge, who had been averaging 9.0 points a game, went over 20 for the second time in three games.