Off to their best start since they opened the 1985-86 season with 16 wins, the Wolverines (14-0, 1-0) had no trouble in the Big Ten opener after breezing through the nonconference portion of their schedule.
They built a 21-point halftime lead with Burke and Hardaway Jr. leading the way.
The Wolverines were never challenged by Northwestern (9-5, 0-1).
Jordan Morgan added 12 points and 13 rebounds for the Wolverines.
Glenn Robinson III and Nik Stauskas scored 10 points apiece.
Jared Swopshire, a transfer from Louisville, and Kale Abrahamson each scored 11 points for Northwestern.
But the Wildcats still gave up the most points they have allowed this season while being outclassed by one of the nation’s best teams.
NO. 3 ARIZONA 92, COLORADO 83 (OT)
In Tucson, Ariz., Kevin Parrom scored five of his 16 points in overtime after Arizona staged an improbable late rally in regulation and the Wildcats escaped with a victory over Colorado in their Pac-12 opener.
Colorado’s Sabatino Chen banked in a 3-pointer at the end of regulation.
But officials waved it off after reviewing the video, saying the ball was on his fingertips as the backboard lights went on to show time had expired.
MISSISSIPPI STATE 97, NEW ORLEANS 47
In Starkville, Miss., Colin Borchert had 17 points and eight rebounds to lead Mississippi State (5-7) over New Orleans (3-9).
Mississippi State (5-7) shot 56.5 percent from the field (35 of 62) and hit a season-high 10 3-pointers.
TEXAS A&M 67, HOUSTON BAPTIST 59
In College Station, Texas, Elston Turner scored 11 of his 17 points in the second half as Texas A&M (10-3) pulled away from Houston Baptist (4-10).