The Zips posted their lowest point total of the season in a 77-61 loss Sunday.
They also made a season-low four 3-pointers and shot 42 percent overall.
“You could see those two games in three weeks hurt us,” Akron coach Keith Dambrot said. “We just didn’t have any juice and life.”
Doug McDermott scored 30 points for Creighton, which broke away late in the first half.
McDermott, who made a career-high six 3-pointers, also had 30 points against Wisconsin last month for the Bluejays (9-1).
The Bluejays shot 48 percent and made 10 of 22 3-pointers.
Zeke Marshall and Nick Harney both had 12 points for Akron (4-3).
NO. 21 UNLV 76, CALIFORNIA 75
In Berkeley, Calif., Quintrell Thomas grabbed Anthony Marshall’s airball under the basket and scored on a short hook shot with 1.2 seconds remaining to lift No. 21 UNLV to win over California (6-2).
The Runnin’ Rebels’ Anthony Bennett had career-highs of 25 points and 13 rebounds while leading UNLV (7-1) to its sixth consecutive win.