Jack Cooley and Jerian Grant each had 13 points for the Fighting Irish (7-1), who opened an 11-point lead by halftime and were never threatened the rest of the way.
Notre Dame outplayed Kentucky (4-2) inside during the first half and held the Wildcats to a season-low 40 percent shooting for the game.
Julius Mays led Kentucky with 16 points.
ST. JOHN’S 89, SOUTH CAROLINA 65
In New York, D’Angelo Harrison broke the 20-point mark for the sixth time in seven games this season, finishing with 26 and St. John’s beat South Carolina in the Southeastern Conference-Big East Challenge.
The Red Storm (5-2) led 38-26 at halftime and pulled away over the final 10 minutes, leading by as many as 28 points in the final minutes.
Michael Cabrera had 11 points and 11 rebounds for the Gamecocks (5-2), who were playing their first true road game of the season.
South Carolina junior guard Brenton Williams was taken from the court on a stretcher after falling and injuring his neck when he was fouled on a drive to the basket.
A school spokeswoman said Williams was taken to a hospital for evaluation and that he had movement in his extremities.
NO. 5 NOTRE DAME 72, CENTRAL MICHIGAN 63
In Mount Pleasant, Mich., Skylar Diggins scored 17 of her 25 points in the first half, and Notre Dame (5-0) pulled away late in a victory over Central Michigan (2-3).
Ariel Braker added 10 points and eight rebounds to help the Fighting Irish close November undefeated for the first time since the 2009-10 season.
MIAMI 69, NO. 6 PENN STATE 65
In Coral Gables, Fla., Morgan Stroman scored 15 points, leading Miami (5-1) over Penn State (5-1).
Suriya McGuire’s layup with 14 seconds left broke a 65-all tie. Alex Bentley had a chance to tie it but her jumper with 5 seconds left bounced off the rim.