Manziel, a redshirt freshman, completed 30 of 36 passes. He ran for a 37-yard touchdown in the second quarter that helped the Aggies build a 31-0 lead by early in the second half.
The Southeastern Conference’s leading rusher added an 8-yard touchdown run in the fourth quarter.
Texas A&M (7-2, 4-2 SEC) has won all five of its road games this season. Christine Michael rushed for 50 yards and two touchdowns. The Aggies gained 693 total yards.
Mississippi State (7-2, 3-2) has lost two in a row. Tyler Russell completed 19 of 30 passes for 212 yards, with one touchdown and one interception.
VANDERBILT 40, KENTUCKY 0
In Lexington, Ky., Vanderbilt dominated Kentucky on offense, defense and special teams to jump to a 27-point halftime lead and coasted.
The Commodores (5-4, 3-3 Southeastern Conference) scored touchdowns on four of their five first-half drives, none of which took longer than 4 minutes, 19 seconds.
Jordan Rogers drove Vanderbilt 71 yards on 11 plays to begin the game, ending with a 34-yard touchdown pass to Jordan Matthews. Rodgers also threw a 30-yard touchdown pass to Chris Boyd in the second quarter and finished 18-of-29 for 220 yards with one interception.
The Wildcats (1-9, 0-7) were outgained 447 yards to 260, but it was miscues on special teams that hurt them the most.
TENNESSEE 55, TROY 48
In Knoxville, Tenn., Marlin Lane rushed for a tiebreaking 9-yard touchdown with 1:25 remaining Saturday as Tennessee rallied to edge Troy in a game that featured 1,439 combined yards in total offense, the most ever in a Tennessee football game.
Tennessee (4-5) gained 718 yards, the most in school history. Troy (4-5) compiled 721 yards, the most ever by a Tennessee opponent.
Justin Hunter caught nine passes for 181 yards and three touchdowns for the Volunteers.
ARKANSAS 19, TULSA 15
In Fayetteville, Ark., Dennis Johnson rushed for 109 yards and two touchdowns, and Cobi Hamilton set the school’s single-season receptions record, as Arkansas rallied for a win over Tulsa.
The win keeps the slim bowl chances alive for the Razorbacks (4-5) with three games remaining, and it extends their winning streak to 18 games over the Golden Hurricane (7-2).
AUBURN 42, NEW MEXICO STATE 7
In Auburn, Ala., Tre Mason rushed for 152 yards and Onterio McCalebb added 113 and two touchdowns to help Auburn snap a five-game losing streak with a victory over New Mexico (1-8).
Daren Bates returned a fumble for a 62-yard touchdown for the Tigers (2-7), who picked up a much-needed win in the program’s worst start in 60 years with games against No. 7 Georgia and No. 1 Alabama looming. It was Auburn’s longest fumble return for a score since 1969.