Manuel completed 27 of 34 passes before leaving early in the fourth quarter with a 48-7 lead.
Florida State (6-1, 3-1 ACC) didn’t waste any time shaking off over last week’s 17-16 loss at North Carolina State.
Hopkins passed the previous league scoring record of 393 points with a 51-yard field goal that gave the Seminoles a 31-7 halftime lead.
NORTH CAROLINA 18, MIAMI 14
In Miami, Giovani Bernard ran for two touchdowns and North Carolina survived a slew of penalties to beat Miami, handing the Hurricanes their first Atlantic Coast Conference loss.
Bernard scored on runs of 10 and 17 yards for the Tar Heels (5-2, 2-1). It was the fourth straight win for North Carolina, which was penalized 15 times.
Mike James and Stephen Morris each had touchdown runs for Miami (4-3, 3-1), which may have lost more than a game. Morris, Miami’s quarterback, was helped off the field with 8:26 remaining after apparently hurting his left ankle. He had a large icepack strapped to the ankle shortly afterward and did not return.
VIRGINIA TECH 41, DUKE 20
In Blacksburg, Va., Logan Thomas threw two touchdown passes, J.C Coleman ran for 183 yards and two long touchdowns, and Virginia Tech (4-3, 2-1 Atlantic Coast Conference) fell behind 20-0, then buried Duke.
The Blue Devils (5-2, 2-1) arrived seeking one more victory to become bowl eligible for the first time since 1994. The Blue Devils gained 150 yards in the first quarter but 84 in the next two quarters.
MARYLAND 27, VIRGINIA 20
In Charlottesville, Va., Stefon Diggs returned the opening kickoff 100 yards, and Perry Hils threw for one touchdown and ran for another as Maryland (4-2, 2-0) defeated Virginia.
The Cavaliers (2-5, 0-3) have now lost five in a row.