The Razorbacks were done in by a porous pass defense and three turnovers, as their once-promising season continued to crumble with a fourth consecutive loss.
Arkansas (1-4, 0-2) led 10-7 after one quarter before the Aggies (3-1, 1-1) scored 51 straight points to take the lead and cruise to the win. It broke a three-game losing streak to the Razorbacks, who beat A&M 42-38 last season after trailing 35-17 at halftime.
Manziel added 104 yards rushing to break the school and SEC records for yards of total offense with 557.
Tyler Wilson threw for 373 yards and a touchdown, but he threw two interceptions as Arkansas was shut out after the first quarter.
MISSOURI 21, CENTRAL FLORIDA 16
In Orlando, Fla., Marcus Murphy returned a punt 66 yards for a touchdown and James Franklin added an 80-yard touchdown pass as Missouri ground out a win over Central Florida.
UCF (2-2) trailed 21-10 before a late score, but following a Tigers punt, Knights receiver Jeff Godfrey’s fumble with 2:26 left allowed Missouri (3-2) to hang on.
Coming off a dismal passing performance last week at South Carolina, Franklin was efficient, going 19 for 30 for 257 yards.
NO. 3 LSU 38, TOWSON 22
In Baton Rouge, La., Zach Mettenberger connected with Odell Beckham Jr. five times for 128 yards and two touchdowns, and No. 3 LSU overcame sloppiness in a victory over feisty Towson.
Mettenberger finished with 238 yards passing but his fumble – one of three LSU turnovers – led to the first of two touchdowns by Towson’s Terrance West.
West’s first TD run gave Towson, an FCS team, a stunning 9-7 lead in the second quarter before LSU responded with 24 straight points.
J.C. Copeland, LSU’s 272-pound fullback, scored his third touchdown of the season on a 1-yard plunge, but was hurt in the fourth quarter and did not put any weight on his left leg as he was helped off the field.