Tino Sunseri passed for 283 yards and three touchdowns and freshman running back Rushel Shell added 157 yards as Pitt gave coach Paul Chryst his first career victory in emphatic fashion.
Virginia Tech had won 13 consecutive true road games, the longest active streak in the country.
NO. 5 FLORIDA STATE 52, WAKE FOREST 0
In Tallahassee, Fla., Chris Thompson scored on runs of 74 and 80 yards on successive first-half carries to lead Florida State.
Thompson, who suffered a broken back at Wake Forest a year ago that nearly ended his career, had a career-high 197 yards.
NO. 19 LOUISVILLE 39, NORTH CAROLINA 34
In Louisville, Ky., Teddy Bridgewater threw three first-half touchdowns and Louisville scored on its first six possessions, and then had thwart North Carolina’s comeback with a late defensive stand.
CONNECTICUT 24, MARYLAND 21
In College Park, Md., Lyle McCombs and Scott McCummings both ran for touchdowns, and Nick Williams returned a punt for another touchdown as Connecticut knocked off Maryland.
McCombs rushed for 94 yards and his fourth-quarter touchdown.
MIAMI 38, BETHUNE-COOKMAN 10
In Miami, Duke Johnson finished with four touchdowns, scoring them three different ways and leading Miami past Bethune-Cookman.
NORTHWESTERN 22, BOSTON COLLEGE 13
In Evanston, Ill., Mike Trumpy ran for 106 yards with a late touchdown, and Northwestern beat Boston College.
NORTH CAROLINA STATE 31, SOUTH ALABAMA 7
In Raleigh, N.C., Mike Glennon threw three touchdown passes Saturday to help North Carolina State beat South Alabama
DUKE 54, NORTH CAROLINA CENTRAL 17
In Durham, N.C., Sean Renfree passed for 274 yards and three touchdowns to lead Duke.