Reggie Bullock added 11 points in his first career start for the Tar Heels (17-3, 4-1 Atlantic Coast Conference), who had no trouble winning their 11th in a row against their longtime rivals.
North Carolina State (15-6, 4-2) was off to its best start in the conference league in six years. But with its bigger front line dominating inside, North Carolina shot 48 percent and led by 31 points in the second half.
Scott Wood scored 11 points to lead the Wolfpack.
NO. 14 FLORIDA 64, MISSISSIPPI 60
In Oxford, Miss., Patric Young scored 15 points, Kenny Boynton added 12 and Florida (16-4, 4-1 Southeastern Conference) rallied from a double-digit first-half deficit to beat Mississippi (13-7, 3-3).
Florida fell behind 20-4 in the opening minutes and trailed 38-28 at halftime.
NO. 25 WISCONSIN 57, NO. 16 INDIANA 50
In Madison, Wis., Ben Brust scored 13 points and Wisconsin (17-5, 6-3) continued its recent rebound in the Big Ten, beating Indiana (16-5, 4-5).
NO. 19 VIRGINIA 66, BOSTON COLLEGE 49
In Charlottesville, Va., Mike Scott scored 18 points and Virginia pulled away from a 44-all tie with a 22-3 run and beat Boston College.
The victory was just the second in the past seven games against the Eagles (7-13, 2-4) for the Cavaliers (16-3, 3-2).