The Orange (21-1, 8-1 Big East) used a late 12-2 run to pull away from the Bearcats (15-6, 5-3), who failed to turn the energy from their first home sellout into a signature win.
Instead, Boeheim came away with career victory No. 877, moving him ahead of Adolph Rupp into sole possession of fourth place on the Division I coaching list.
NO. 5 KANSAS 64, TEXAS A&M 54
In Lawrence, Kan., Thomas Robinson carried Kansas when things looked bleak, scoring 16 of his 18 points in the second half and leading the Jayhawks to a win over scrappy Texas A&M.
Kansas (17-3, 7-0 Big 12) is 18-1 against Texas A&M (11-8, 2-5), the lone loss coming in February 2007.
NO. 2 NOTRE DAME 72, NO. 7 TENNESSEE 44
In South Bend, Ind., Skylar Diggins matched a season high with 27 points and Notre Dame routed Tennessee, holding the Vols (14-5) to their lowest scoring output in school history.
Devereaux Peters had 16 points and 16 rebounds for the Irish (20-1), who have won 17 in a row.
NO. 10 MIAMI 79, VIRGINIA TECH 48
In Coral Gables, Fla., Stefanie Yderstrom scored 22 points to lead Miami (17-1, 6-1 Atlantic Coast Conference) over Virginia Tech (6-14, 2-5).
NO. 13 PURDUE 67, MICHIGAN STATE 49
In West Lafayette, Ind., Alex Guyton and Chelsea Jones each scored 12 points to help Purdue (17-3, 7-0 Big Ten) defeat Michigan State (12-8, 4-3) .