The school said the sophomore was driving from his home in Central, S.C., to meet teammates on campus Tuesday morning when he was in a crash.
Hopkins is Clemson’s second-leading receiver, with 62 receptions for 871 yards and four touchdowns this season.
Coach Dabo Swinney said he did not know if Hopkins would be able to play in the bowl game.
PENN STATE: The Nittany Lions have opened their bowl preparations without quarterback Matt McGloin in uniform.
McGloin was in street clothes Tuesday when the Nittany Lions started practice at a Dallas-area high school.
Before Christmas, he hit his head during a locker-room scuffle with receiver Curtis Drake. He went into seizure and sustained a concussion. Drake did not make the trip for “personal reasons,” interim coach Tom Bradley said.
Bradley said McGloin will be tested and worked out by team doctors daily to see if he can play against Houston on Monday in the TicketCity Bowl.
NEBRASKA: Offensive lineman Andrew Rodriguez of the 21st-ranked Cornhuskers was ruled out of the Capital One Bowl in Orlando, Fla., against No. 10 South Carolina because of a sprained foot.
Tight end Ben Cotton, who has missed two games with a left shoulder injury, returned to practice and is expected to play in the game on Jan. 2.