The Lady Bears (11-0) won their second No. 1 vs. No. 2 game this season while avenging a one-point loss at Connecticut early last season when the rankings were reversed.
Griner also had nine rebounds and nine blocked shots.
Odyssey Sims had 23 points for the Lady Bears, whose 29-game home winning streak includes a 94-81 win over then-No. 2 Notre Dame in November.
Bria Hartley led Connecticut (9-1) with 25 points, while Kaleena Mosqueda-Lewis had 15.
NO. 3 NOTRE DAME 92,
NO. 8 KENTUCKY 83
In South Bend, Ind., Natalie Novosel’s 23 points led five Irish women in double figures, Skylar Diggins had a double-double with 16 points and 11 assists, and Notre Dame (10-1) handed Kentucky (10-1) its first loss of the season.
After trailing by as much as 10 in the second half, Samantha Drake made a layup to give Kentucky a 75-74 lead with 5:07 to play.
But Novosel made a pair of free throws and Devereaux Peters scored on a layup. After a missed Kentucky 3-pointer, Diggins coolly drilled a 3 – her first of the game.
NO. 10 TEXAS A&M 71, SOUTHERN CAL 70
In College Station, Texas, Sydney Carter made a 3-pointer with 10 seconds left and Texas A&M rallied for its 47th consecutive nonconference home win.
Southern Cal (4-5) led 69-61 with 2:34 remaining before Texas A&M (8-2) took over. Ashley Corral missed a 3-point attempt for the Trojans with 4 seconds remaining.
NO. 11 RUTGERS 62, IONA 29
In Piscataway, N.J., April Sykes scored 18 points and Rutgers (10-2) held Iona to just two baskets in the second half.
Rutgers let a 23-15 halftime lead dwindle to four, missing 11 of its first 12 shots to start the second half. Betnijah Laney finally ended the drought, hitting a 3-pointer from the corner with 11:21 left. Then her classmates took over during a 36-7 run to close the game.
NO. 16 PENN STATE 103, WAGNER 42
In State College, Pa., Alex Bentley and Maggie Lucas each scored 23 points to lead Penn State (9-2).
Penn State held Wagner to 16 percent shooting in the first half and led 57-19 at the break.
SOUTH CAROLINA 79,
NO. 18 NORTH CAROLINA 48
In Myrtle Beach, S.C., La’Keisha Sutton scored 21 points, Markeshia Grant added 20 and South Carolina (9-2) held North Carolina (7-2) to its lowest point total in nearly two years.
The Gamecocks broke out to an 11-0 lead and never let up against the Tar Heels, who came in as the nation’s highest-scoring team at 87.5 points a game.
North Carolina’s point total was its lowest since an 88-47 loss to Connecticut on Jan. 9, 2010.
NORTH CAROLINA STATE 66,
NO. 20 VANDERBILT 59
In Raleigh, N.C., Kody Burke scored a career-high 21 points and North Carolina State (7-3) held on for the victory.
Stephanie Holzer scored 15 points and Christina Foggie had 13 for Vanderbilt (10-1).
NO. 22 PURDUE 62, AUBURN 54
In Auburn, Ala., Alex Guyton scored a career-high 19 points and Purdue (8-3) hit its free throws late in the game to hold on for the victory.
NO. 25 NEBRASKA 94, VERMONT 41
In Lincoln, Neb., Jordan Hooper scored 21 points and Nebraska (10-1) broke away in the second half.
NORTH CAROLINA CENTRAL 48
In Clemson, S.C., Clemson hit 11 3-pointers to tie the school mark in a win.
Kelly Gramlich had a career-best 20 points and tied the school record with six 3-pointers, while Nikki Dixon hit four threes on her way to 18 points to pace the Lady Tigers (4-5) in their first meeting with N.C. Central (2-9).