Watford finished with 20 points, giving the Hoosiers their first upset of a top-ranked team since taking down Duke in the 2002 NCAA tournament and setting off a wild scene. Fans stormed the court as officials looked at the replay before counting the basket.
The Hoosiers (9-0) are off to their best start since 1989-90.
Doron Lamb scored 19 points to lead the Wildcats (8-1) and Michael Kidd-Gilchrist added 18 as Kentucky’s three-game winning streak over Indiana ended.
NO. 13 KANSAS 78, NO. 2 OHIO STATE 67
In Lawrence, Kan., Thomas Robinson scored 21 points, Elijah Johnson added 15 and Kansas never trailed against the Buckeyes, who were without forward Jared Sullinger because of an injury.
Freshman reserve forward Kevin Young scored a career-high 14 points, and Tyshawn Taylor had nine points and a career-best 13 assists for the Jayhawks (6-2), who extended their winning streak to 47 games over non-conference opponents at Allen Fieldhouse.
William Buford had 17 of his 21 points in the second half for Ohio State (8-1).
NO. 3 SYRACUSE 85, GEORGE WASHINGTON 50
In Syracuse, N.Y., Dion Waiters had 19 points and six steals, both career highs, and Syracuse beat George Washington with ease.
In the midst of a federal investigation, Syracuse is poised to move to No. 1 in the national rankings, after top-ranked Kentucky and No. 2 Ohio State lost.
NO. 4 NORTH CAROLINA 84, LONG BEACH STATE 78
In Chapel Hill, N.C., John Henson had 24 points and 10 rebounds, and Harrison Barnes added 20 points for North Carolina.
The Tar Heels (8-2) rallied from a 45-40 halftime deficit to win their second straight game in the opener of a monthlong home stand.
NO. 5 LOUISVILLE 80, FAIRLEIGH DICKINSON 58
In Louisville, Ky., Gorgui Dieng had 14 points and 12 rebounds to lift Louisville to its 17th consecutive win at the KFC Yum! Center.
Kyle Kuric added 18 points and Peyton Siva had 16 for Louisville, which is in the midst of a 10-game homestand.
NO. 7 DUKE 86, WASHINGTON 80
In New York, freshman Austin Rivers scored 18 points and the Blue Devils overcame a poor performance from the free throw line at Madison Square Garden.
The Blue Devils (9-1) seemed in control, taking a 19-point lead three times in the second half. But the Huskies (4-4) shook off a terrible first half and chipped away at the deficit.
NO. 8 XAVIER 76, CINCINNATI 53
In Cincinnati, Mark Lyons scored 19 points as Xavier beat its crosstown rival in a game that featured plenty of trash talking and was called with 9.4 seconds left because of a brawl.
Words escalated into shoving and swings as the final seconds ticked down. Both benches cleared and coaches pulled their players away. The referees called it.
NO. 10 MISSOURI 84, NAVY 59
In Columbia, Mo., Marcus Denmon scored 22 points to help Missouri remain unbeaten and match its best start since the 2006-07 season.
Ricardo Ratliffe made 6 of 9 shots and had 14 points, and Kim English chipped in 13 for the Tigers (9-0).
NO. 14 WISCONSIN 62, UNLV 51
In Madison, Wis., reserve Ben Brust hit all seven of his 3-point attempts and finished with a career-high 25 points for the Badgers.
Wisconsin (8-2) went on a 13-0 run midway through the first half to take a 31-15 lead. The Badgers pushed the advantage to 19 before the Rebels (9-2) cut it to 36-23 at the half.
NO. 15 PITTSBURGH 74, OKLAHOMA ST
In New York, Ashton Gibbs scored 17 points, including three free throws in the final 17 seconds as Pitt sent Oklahoma State to its third loss – all of them at Madison Square Garden.
NO. 17 MISSISSIPPI STATE 106, TROY 68
In Starkville, Miss., Dee Bost scored a season-high 28 points, and Arnett Moultrie added 20 points and 12 rebounds for Mississippi State.
The Bulldogs (9-1) won their eighth straight game, shooting 56.3 percent (40 of 71) from the field, including 51.6 percent (16 of 31) from 3-point range.
NO. 18 GEORGETOWN 62, HOWARD 48
In Washington, playing its first game this season as a ranked team, Georgetown held Howard scoreless for nearly 10 minutes at the start then staved off a strong comeback bid.
SAINT JOSEPH’S 80, NO. 19 CREIGHTON 71
In Philadelphia, Carl Jones scored 29 points, Ronald Roberts and Langston Galloway each had 12, and Saint Joseph’s spoiled Creighton’s first week in the Top 25 in five years.
NO. 20 MICHIGAN 90, OAKLAND 80
In Auburn Hills, Mich., Tim Hardaway Jr. scored 18 of his 21 points in the second half and Evan Smotrycz had a career-high 20 points and nine rebounds for Michigan.
NO. 25 HARVARD 76, BOSTON UNIVERSITY 52
In Boston, Kyle Casey had 20 points and nine rebounds to lead Harvard, giving the Crimson hope of holding onto their first-ever ranking in the AP top 25.