The Irish (8-1, 1-0 Big East) scored 51 points in the first half for the third time this season as they won their fifth game in a row.
Natalie Novosel and Brittany Mallory 11 scored 11 points for Notre Dame.
Sarina Simmons led Marquette (5-5, 0-1) with 14 points.
NO. 16 TEXAS TECH 88, TEXAS-ARLINGTON 48
In Lubbock, Texas, Casey Morris scored 22 of her career-best 24 points in the first half and Texas Tech cruised to a victory over Texas-Arlington.
Morris scored the first eight points for Texas Tech and hit three 3-pointers as the Lady Raiders (8-0) jumped out to a 20-1 lead. She finished with six 3s.
NO. 18 NORTH CAROLINA 95, LIPSCOMB 53
In Chapel Hill, N.C., Chay Shegog had a career-high 26 points and 11 rebounds, leading North Carolina over Lipscomb.
It was the senior center’s third double-double of the season.
The Tar Heels (6-1), who hadn’t played since their 103-84 loss at then-No. 16 Penn State last Wednesday, got a career-high 21 points and 11 rebounds from Krista Gross for her first double-double of the season.
NO. 19 GEORGETOWN 82, PITTSBURGH 54
In Pittsburgh, Sugar Rodgers scored 28 points to lead Georgetown over Pittsburgh in the Big East opener for both teams.
The Hoyas (8-2, 1-0) used aggressive defense to run away from the Panthers (4-5, 0-1) early. Pitt shot just 6 of 34 in the first half and 26.7 percent for the game.
Taylor Brown and Tia Magee each added 12 points for the Hoyas, with Magee pulling down seven rebounds.
Asia Logan led Pitt with 15 points.
NO. 22 DEPAUL 69, ST. JOHN’S 52
In Chicago, Keisha Hampton scored 21 points, while Anna Martin and Jasmine Penny added 13 apiece to lead DePaul to its fifth consecutive win.
The Red Storm (5-4, 0-1 Big East) crept to within six points at 50-44 with 9:16 to play but never got closer as Hampton scored seven points in a 19-8 Blue Demons surge.
NO. 23 VANDERBILT 99, UT-MARTIN 84
In Martin, Tenn., Jasmine Lister scored 30 points, Christina Foggie added 20 and Vanderbilt remained unbeaten with a win over Tennessee-Martin.
Lister made her first seven shots, six of them 3-pointers. Vanderbilt (10-0) shot 60 percent for the game and 70.6 percent from 3-point range.
Jasmine Newsome led UTM (4-4) with 28 points and Rickiesha Bryant had 18.