Kayla McBride chipped in with 10 points and nine rebounds for Notre Dame (6-1), which jumped out to a 14-3 lead and pressured the Quakers into 23 turnovers, including 15 on steals.
Kara Bonenberger had nine points and seven rebounds to lead Penn (4-2). Alyssa Baron, who came in averaging better than 20 points, was held to seven.
Notre Dame outrebounded Penn 49-34.
Peters scored eight points and Novosel had the other six during Notre Dame’s opening 14-3 run, while the Quakers made only one of their first ten shots. The Irish broke off a 14-0 run later in the first half for a 32-7 lead with 6:32 to go before halftime.
Notre Dame opened the second half on a 16-8 run to put the game out of reach.
NO. 11 RUTGERS 69, FLORIDA 49
In Daytona Beach, Fla., Erica Wheeler scored 15 points to help Rutgers remain unbeaten.
April Sykes and Monique Oliver added 12 points each, and Betnijah Laney had 10 for the Scarlet Knights, who are off to their first 8-0 start since 2005.
Jordan Jones scored 20 points to lead turnover-plagued Florida (6-2).
The Gators hit only 2 of its first 11 shots to open the second half and committed 22 miscues that Rutgers turned into 22 points.
Deana Allen added 11 points for the Gators, who had won six in a row.
NO. 23 WIS-GREEN BAY 66, MARQUETTE 50
In Green Bay, Wis., Adrian Ritchie scored 15 points to lead four players in double figures and help Wisconsin-Green Bay beat Marquette.
Julie Wojta had 12 points and 12 rebounds, and Lydia Bauer had 12 points and grabbed 10 boards for the Phoenix (6-0).
Green Bay led 29-28 at halftime thanks to 15 turnovers and 13 fouls by Marquette.
Katherine Plouffe scored 15 points for Marquette (4-4).
NO. 25 VANDERBILT 77, DENVER 56
In Nashville, Tenn., Christina Foggie scored 18 of her 23 points in the first half to lead Vanderbilt to a victory over Denver.
Foggie eclipsed 20 points for the third straight game, knocking down a career-high six 3-pointers for the Commodores (8-0).
Denver’s sloppiness accounted for a 28-point halftime deficit.
The Pioneers (5-2) committed a season-high 23 turnovers, with Vanderbilt scoring 33 points off the Denver miscues.