The Cougars (12-0, 8-0) set a school season record by winning their 12th game.
If they can make it 13 in a row in the C-USA title game at home on Dec. 3, against either Southern Mississippi or Marshall, the Cougars will earn their first BCS bid.
They would become from first team from the conference to play in the Bowl Championship Series.
NO. 22 NEBRASKA 20, IOWA 7
In Lincoln, Neb., Rex Burkhead, who started the week with his right foot in a walking boot, ran for 160 yards and a touchdown on a school-record 38 carries and Nebraska defeated Iowa.
LOUISVILLE 34, SOUTH FLORIDA 24
In Tampa, Fla., Louisville got three touchdown passes from freshman quarterback Teddy Bridgewater to defeat South Florida and clinch a share of the Big East title.
BOSTON COLLEGE 24, MIAMI 17
In Miami, Luke Kuechly ran an interception back for a touchdown and became Boston College’s all-time tackles leader, and the Eagles picked Jacory Harris off four times in his final college game en route to beating Miami.
WEST VIRGINIA 21, PITTSBURGH 20
In Morgantown, W.Va., Shawne Alston rushed for two second-half touchdowns, including a 1-yarder with 6:10 left, and West Virginia came from 10 points down to beat Pittsburgh.
CENTRAL FLORIDA 31, TEXAS-EL PASO 14
In Orlando, Fla., Latavius Murray rushed for a career-high 233 yards and scored three times to help Central Florida rout Texas-El Paso in the season finale for both teams.