The Aggies built a 20-3 halftime lead before the Cowboys (4-0, 1-0 Big 12) took advantage of three Texas A&M turnovers and numerous penalties to reel off 27 straight points to take a 30-20 lead.
Jeff Fuller caught a 4-yard TD pass with 2:20 remaining for A&M’s first score since the second quarter to get A&M within 30-27.
Texas A&M’s defense forced a punt and the Aggies (2-1, 0-1) got the ball back with almost two minutes remaining, but Ryan Tannehill threw his third interception to seal the Cowboys’ win.
NO. 1 OKLAHOMA 38, MISSOURI 28
In Norman, Okla., Landry Jones threw for 448 yards and three touchdowns to Ryan Broyles, leading Oklahoma back from a rare home deficit to beat Missouri.
NO. 4 BOISE STATE 41, TULSA 21,
In Boise, Idaho, Kellen Moore tossed four touchdown passes, a pair to Tyler Shoemaker, in less than 2½ quarters, Jerrell Givens intercepted Tulsa quarterback G.J. Kinnie twice and Boise State rolled in its home opener.
NO. 6 WISCONSIN 59, SOUTH DAKOTA STATE 10
In Madison, Wis., Nick Toon had a career-high 155 yards receiving and two touchdowns, helping Wisconsin rout South Dakota at Camp Randall Stadium.
Russell Wilson had another big day for the Badgers, completing 19 of 25 passes for 345 yards and three touchdowns.
NO.9 NEBRASKA 38, WYOMING 14
In Laramie, Wyo., Rex Burkhead rushed for two touchdowns and a career-high 170 yards and Taylor Martinez threw for 157 yards and a score to lead Nebraska to an easy win over Wyoming .
The Huskers rolled up 490 yards total offense, including 333 on the ground, in their first road game of the season and last game before their highly anticipated Big Ten opener at Wisconsin next weekend.
NO. 17 BAYLOR 56, RICE 31
In Waco, Texas, Robert Griffin III continued his incredible feat of throwing more touchdown passes than incompletions, tossing for five scores and running for another to lead Baylor to a victory over Rice.
Griffin was 29 of 33 for 338 yards, upping his season totals to 13 touchdowns and 12 incompletions.
NO. 18 SOUTH FLORIDA 52, TEXAS-EL PASO 24
In Tampa, Fla., B.J. Daniels threw for 202 yards and ran for 130 more, leading South Florida over Texas-El Paso.
Daniels scored on a 71-yard run on the Bulls’ second offensive play and threw touchdown passes of 54 and 18 yards to Lindsey Lamar in the second half.
NO. 20 TEXAS CHRISTIAN 55, PORTLAND STATE 13
In Fort Worth, Texas, Texas Christian scored three touchdowns in a span of 1:18 just before halftime and Waymon James ran 65 yards for a score on the first play of the second half as the Horned Frogs rolled.
NO. 22 MICHIGAN 28, SAN DIEGO STATE 7
In Ann Arbor, Mich., quarterback Denard Robinson ran for three scores in the first half to give Michigan a three-touchdown lead and finished with a season-high 200 yards rushing, helping the Wolverines win.
Robinson completed just 8 of 17 passes for 93 yards with two interceptions in a miserable second half.
NO. 24 ILLINOIS 23, WESTERN MICHIGAN 20
In Champaign, Ill., Troy Pollard carried the ball for a career-high 133 yards and Illnois needed all three of Derek Dimke’s field goals to survive Western Michigan.
The Illini trailed at the half 13-10.
The game was tied 20-20 with less than nine minutes to play before Illinois rallied.
NOTRE DAME 15, PITTSBURGH 12
In Pittsburgh, Notre Dame quarterback Tommy Rees shrugged off a miserable first three quarters to hit tight end Tyler Eifert for a 6-yard touchdown with less than 7 minutes to go and lift the Fighting Irish over Pittsburgh.
PENN STATE 34, EASTERN MICHIGAN 6
In State College, Pa., Matt McGloin threw for three touchdowns and Penn State welcomed coach Joe Paterno back to the sideline with a win over Eastern Michigan.
Penn State held the Eagles to 68 on the ground – 221 below its season average.
OHIO STATE 37, COLORADO 17
In Columbus, Ohio, Braxton Miller tossed two touchdown passes to Devin Smith as Ohio State rolled.