Connecticut (23-1, 11-0 Big East) overcame its second halftime deficit of the season and 17 turnovers to beat West Virginia for the 23rd consecutive time.
West Virginia (20-5, 6-5) couldn't keep the momentum of a strong first half going and lost for the fourth time in five games.
Connecticut trailed 29-27 at halftime and didn't take its first lead until early in the second half. Moore scored 15 points after halftime, including eight in a row for the Huskies down the stretch to dash West Virginia's hopes for the school's biggest upset.
NO. 8 NOTRE DAME 89,
SETON HALL 38
In South Bend, Ind., Skylar Diggins scored 14 points and Notre Dame routed Seton Hall.
Jasmine Crew led the Pirates in scoring with 10 points despite fouling out with 10:18 remaining in the game. Seton Hall (7-16) has yet to win a Big East matchup in 10 tries this season.
Diggins added six assists, seven rebounds, and five steals for Notre Dame (21-4, 10-1), which made its first nine field goal attempts.
NO. 10 DEPAUL 77,
In Syracuse, N.Y., Deirdre Naughton hit five 3-pointers, matching her total for the season, and finished with a season-high 19 points to lead DePaul.
DePaul (22-3, 9-1 Big East), coming off an 89-66 loss at No. 2 Connecticut, was an impressive 13 of 23 (56.5 percent) from beyond the arc as the Blue Demons tied Notre Dame for second in the conference.