Markieff Morris added 16 points for the Jayhawks (23-1, 8-1), who beat their archrivals at home for the 12th time in a row. Missouri (18-6, 4-5) dropped to 0-5 in conference road games and 14-41 all-time in Allen Fieldhouse.
Kansas came in leading the nation with a 52 percent field goal percentage and shot 61 percent against Missouri's pressure defense. The Tigers made seven of their first nine shots and wound up shooting 52 percent.
Laurence Bowers, who fouled out with a little less than 51/2 minutes to go, had 19 points for Missouri, and Phil Pressey had 17.
NO. 4 PITTSBURGH 71,
NO. 25 WEST VIRGINIA 66
In Morgantown, W.Va., Nasir Robinson scored 15 points and Pittsburgh overcame an awful start to beat West Virginia.
Pittsburgh (22-2, 10-1 Big East) got a balanced attack without leading scorer Ashton Gibbs, who is out up to two weeks with a left knee injury. Gary McGhee had 13 points, Travon Woodall added 12 and Brad Wanamaker scored 11 for the Panthers.
Pittsburgh went hard to the glass after being held to a season-low 23 points in the first half. The Panthers went ahead to stay with eight minutes left in the game to improve to 5-0 on the road in the Big East and continue their best overall start in conference play.
This is the 10th consecutive season Pitt has won at least 20 games overall and at least 10 in the Big East, the conference's longest current streak.
Deniz Kilicli scored a career-high 19 points and Kevin Jones added 12 for the Mountaineers (15-8, 6-5).
The Panthers, who lead the nation in rebounding margin, outrebounded West Virginia 40-28 on the strength of 18 offensive boards.