Thomas had touchdown runs of 1 and 6 yards, plus caught a 17-yard scoring pass from Christian Ponder -- all in the game's first 21 minutes for the Seminoles (5-1, 3-0 Atlantic Coast Conference).
Thompson had a 90-yard touchdown run -- the longest ground gain ever against Miami -- with 4:24 left to seal it for Florida State, which also got TDs from Lonnie Pryor and Rodney Smith. Ponder threw for 173 yards and two touchdowns.
Jacory Harris was 19 of 47 for 225 yards for Miami (3-2, 1-1), plus ran for a score. Damien Berry ran for 101 yards and a touchdown.
NORTH CAROLINA STATE 44, BOSTON COLLEGE 17
In Raleigh, N.C., Russell Wilson threw for 328 yards and three touchdowns to help North Carolina State beat Boston College, giving Tom O'Brien his first win against his former program.
Owen Spencer, Darrell Davis and Jarvis Williams had TD catches for the Wolfpack (5-1, 2-1 Atlantic Coast Conference), who dominated the Eagles (2-3, 0-2) the entire way. D.J. Green recovered a blocked punt in the end zone for a first-quarter touchdown, while C.J. Wilson returned an interception for a score in the third.
NAVY 28, WAKE FOREST 27
In Winston-Salem, N.C., Ricky Dobbs led a brilliant touchdown drive capped by a 6-yard pass to Greg Jones with 26 seconds left to give Navy a win and hand Wake Forest its second consecutive last-minute loss.
Dobbs, who had been knocked out of the game briefly after taking a sack on the previous drive, found an open Gee Gee Greene for a 34-yard gain to the Wake Forest 15 with just over a minute left.
Then on third down he hit Jones in the right corner of the end zone.
Joe Buckley kicked the tiebreaking extra point and Navy (3-2) avoided a second loss in a row.
Freshman Tanner Price threw for 327 yards and two touchdowns and ran for another score for Wake Forest (2-4), which lost its fourth in a row.
The Demon Deacons were beaten by Georgia Tech a week ago on a touchdown with 15 seconds left.
VIRGINIA TECH 45, CENTRAL MICHIGAN 21
In Blacksburg, Va., quarterback Tyrod Taylor rushed for 127 yards and two touchdowns and threw for another score to lead Virginia Tech past Central Michigan.
The Hokies (4-2), who have won four consecutive since losing their first two games, scored 38 unanswered points after the Chippewas (2-4) scored on the game's opening possession.