Wofford's Terriers, who were picked to finish sixth in the nine-team league in the preseason, turned out to have a little more bite.
Georgia Southern battled from behind throughout the night but fell to the Terriers 33-31 before 21,403 fans -- the 10th largest crowd in Paulson history.
It was a continuance of wild finishes and visiting team wins in a series that has heated up in recent years.
The home team hasn't won since 2005.
"Losing isn't fun, no matter how it happens," said Georgia Southern coach Jeff Monken, whose squad slipped to 3-2, 1-1 in conference play.
This dogfight took its final turn with five minutes and 52 seconds left when Eric Breitenstein scored on a 5-yard run to overcome Southern's only lead, which lasted less than 4 1/2 minutes.
Breitenstein's touchdown trumped Darreion Robinson's electrifying 78-yard touchdown run that gave Georgia Southern a 31-27 advantage.
In the final minute, without a timeout, the Eagles marched to Wofford 37. But a 7-yard loss on a draw play took Southern out of field-goal range.
On fourth down, Wofford's Alex Goltry sacked quarterback Jaybo Shaw.
Georgia Southern came in ranked 13th in the Football Championship Subdivision coaches poll.
"We had a reality check," Shaw said. "Rankings are great, but we have to back it up, too."
The Terriers jumped the Eagles at the start. Wofford needed just six plays to go 75 yards for a touchdown and was almost equally effective with seven plays going 58 yards for a touchdown on its second possession.
Mike Rucker scored first on a 36-yard run and Donovon Johnson capped the second on a 14-yard draw up the middle.
During the final minutes of the half, Georgia Southern faked a punt on fourth down from its own 48. Defensive lineman Dion DuBose took the direct snap and rumbled 12 yards for the first down.
The play set up Shaw's 2-yard quarterback sneak for a touchdown with 31 seconds remaining in the half to make it 14-12.
Wofford regained its composure to begin the second half and a 52-yard touchdown pass from Mitch Allen to Brenton Bersin made it 21-12.
Georgia Southern made it 21-19 when linebacker E.J. Webb fell on a fumble in the end zone.
The extra point by Mora was his 68th in a row and broke the school record of 67 set by Reed Haley during the 1992-94 season.