With last year's top receiver Demaryius Thomas and top rusher Jonathan Dwyer gone to the NFL as juniors, Nesbitt kept the offense moving despite his inability to establish a passing game. Nesbitt was only 1 for 6 passing for 8 yards with an interception in the Yellow Jackets' run-based option offense.
South Carolina State sophomore Asheton Jordan had 17 carries for 125 yards and set up the Bulldogs' only touchdown with a 55-yard run to the Georgia Tech 3 in the third quarter. Quarterback Malcolm Long then scored from a yard out.
Jones had touchdown runs of 1 and 15 yards. Tevin Washington, who replaced Nesbitt late in the third quarter, added an 11-yard touchdown run in the fourth quarter as Georgia Tech had 372 yards rushing with six touchdowns.
Anthony Allen, who replaced Dwyer as the featured "B-back" in the spread option offense, had six carries for 28 yards.
Georgia Tech led 20-3 at halftime and pulled away with two quick touchdowns after the break.
Georgia Tech's Quentin Sims recovered a fumbled punt return by Lennel Elmore to give the Yellow Jackets the ball the South Carolina State's 21 early in the third quarter. Nesbitt scored on a fourth-down keeper from the 14.
A 25-yard punt by South Carolina State's Blake Erickson, who had a 16-yard punt earlier in the game, set up Jones' 15-yard scoring run for a 34-3 lead.
Nesbitt had two touchdown runs on fourth-down plays, including his 35-yard run on a fourth-and-3 play on the Yellow Jackets' first possession.
Erickson kicked a 28-yard field goal in the first quarter to end a 17-play drive. The Bulldogs had first down on the Georgia Tech 5 but were kept out of the end zone.
Long was 11 for 25 passing for 94 yards for South Carolina State, an FCS team from the Mid-Eastern Athletic Conference.