Three double-digit seeds in Sweet 16

Brackets across the country are obliterated. Underdogs, meanwhile, keep moving on.

No. 12 seed Cornell upset Wisconsin on Sunday to join No. 11 Washington and No. 10 Saint Mary's among the 16 teams left in the NCAA Tournament -- three double-digit seeds who know precisely how to put the madness in March.

It didn't stop there.

No. 9 Northern Iowa was the double-digit underdog that took apart the tournament favorite, Kansas, while No. 6 Xavier and No. 5 Butler were two of five mid-major teams that advanced.

Americans love underdogs, but many fans who filled out brackets suffered after this kind of uprising.

Michigan State, a No. 5 seed in the Midwest, is the only remaining program from last year's Final Four.

The new odds-on favorite is Kentucky, which breezed through its two games and is listed at 2-1 in Vegas to win the championship, April 5 in Indianapolis.

Before that, though, are the regionals in Salt Lake City, St. Louis, Houston and Syracuse, N.Y.

In the Midwest on Friday, Northern Iowa will face Michigan State and No. 2 Ohio State plays No. 6 Tennessee.

In the East on Thursday, No. 1 Kentucky plays Cornell -- Big Blue vs. the Big Red -- while Washington faces No. 2 West Virginia.

In the South semifinals Friday, No. 3 Baylor will play Saint Mary's, while No. 1 Duke plays No. 4 Purdue.

And the West is mid-major country: No. 2 Kansas State advanced to play Xavier, and No. 1 Syracuse will play Butler on Thursday.

The Bulldogs and Musketeers used to be among the poster children for the small-school darlings. But in a sign of how upside-down this tournament has been, their trips to the regional semis haven't made a huge splash outside of their hometowns of Indianapolis and Cincinnati.