The Gamecocks (9-0) built a five-run lead in the third inning against the Tigers (6-3). South Carolina won 9-6 on Friday night.
Wynkoop (3-0) scattered nine hits and Joel Seddon worked three innings of hitless to earn the save.
Clemson cut the lead to 5-2 in the fifth on Chris Okey’s RBI groundout, but could get no closer.
USC AIKEN 9-9, FLAGLER 8-10
In St. Augustine, Fla., USC Aiken and Flagler split one-run games, with the Pacers winning the opener and the Saints taking the second game.
TJ Costen hit a grand slam in the seventh inning of the opener for USC Aiken (11-3, 4-1 Peach Belt).
Nick Kranick hit a three-run homer in the eighth to lead Flagler (9-6, 3-5) in Game 2.
CLAFLIN 7-2, PAINE 2-7
In Orangeburg, S.C., Avery Wilson and Joseph Graves drove in two runs each as Paine beat Claflin to salvage the second game of a doubleheader.
The Panthers (4-7, 1-1 Southern Intercollegiate Athletic Conference won the opener.
Dalton Self (1-2) went the distance in the second game for the Lions (2-9, 1-1), allowing two runs in seven innings. He struck out six.
GEORGIA 6, BINGHAMTON 2
In Athens, Ga., Conor Welton and Daniel Nichols had three hits each and combined to drive in three runs as Georgia (4-6) beat Binghamton.
GEORGIA TECH 8, BOWLING GREEN 3
In Atlanta, Daniel Spingola homered and drove in two runs and Elliott Barzilli added two RBI as Georgia Tech (6-4) beat Bowling Green.
GEORGIA SOUTHERN 14, SIU-EDWARDSVILLE 5
In Statesboro, Ga., Dalton Busby and Stryker Brown drove in two runs each as Georgia Southern (8-2) hammered SIU-Edwardsville.
Former Harlem standout Josh Wirsu (2-1) allowed one earned run in six innings to get the win. He struck out seven.