Vasturia hit the first 3 to give the Irish a 63-62 lead early then added a second with 62 seconds left that gave Notre Dame a 66-64 lead. Pat Connaughton then added a pair of free throws to help the Irish overcome a career-high 30 points and 14 rebounds by Clemson's K.J. McDaniels.
The Fighting Irish (13-12, 4-8 Atlantic Coast Conference) avoided falling below .500 for the first time this late in the season since finishing 14-16 during the 1998-99 season in John MacLeod's last year as coach. Clemson (15-8, 6-5) lost back-to-back games for just the second time this season.
Both teams squandered chances to win the game earlier.