The Chanticleers (4-5) came in with just one win this season over a Division I team. But they showed no fear against the Tigers (6-4), leading for the final 27 minutes of the game.
Devin Booker led Clemson with 16 points.
SOUTH CAROLINA 74, APPALACHIAN STATE 69
In Columbia, Lakeem Jackson scored a season-high 16 points to help South Carolina (7-3) outlast Appalachian State (2-8).
Appalachian State pulled within two on a layup by Jay Canty with 21 seconds remaining, but Eric Smith connected on one free throw for the Gamecocks and LaShay Page sank two with four seconds left to seal the win.
NO. 1 DUKE 88, CORNELL 47
In Durham, N.C., Seth Curry scored 20 points, Mason Plumlee added 18 and Duke (10-0) reeled off 23 consecutive points in a rout of Cornell (4-7).
NO. 5 LOUISVILLE 79, FLORIDA INTERNATIONAL 55
In Louisville, Ky., Peyton Siva’s career highs of five 3-pointers and 12 assists helped Louisville (10-1) roll past Florida International (3-5).
Siva finished with 15 points.
It was the first meeting between Cardinals coach Rick Pitino and Richard Pitino, his son and Panthers counterpart.
NO. 6 INDIANA 93, MOUNT ST. MARY’S 54
In Bloomington, Ind., Cody Zeller finished with 16 points and six rebounds, and Christian Watford added 15 points and eight rebounds, leading Indiana (10-1) to a rout of Mount St. Mary’s (4-5).
NO. 8 FLORIDA 82, SOUTHEAST LOUISIANA 43
In Gainesville, Fla., Mike Rosario scored a season-high 20 points to go along with six rebounds, and Florida (8-1) routed Southeastern Louisiana (1-8).
NO. 11 CINCINNATI 60, XAVIER 45
In Cincinnati, Sean Kilpatrick scored 25 points and led a second-half surge that carried Cincinnati (11-0) over Xavier (7-3).
NO. 17 CREIGHTON 71, TULSA 54
In Omaha, Neb., Avery Dingman had 14 of his career-high 21 points in the second half as Creighton (11-) beat Tulsa (6-5).
NO. 22 NOTRE DAME 85, KENNESAW STATE 57
In South Bend, Ind., Jack Cooley had 14 points and 13 rebounds as Notre Dame (11-1) beat Kennesaw State (1-9).
NO. 24 OKLAHOMA STATE 69, TEXAS-ARLINGTON 44
In Stillwater, Okla., Markel Brown scored 17 points and Phil Forte added 13 to lead Oklahoma State (9-1) over Texas-Arlington (5-3).