The Wolverines (4-2) had lost four in a row in the conference's annual matchups. This time, though, they used freshman Smotrycz and Tim Hardaway Jr. to build a big lead that Clemson (5-2) could not overcome.
Smotrycz had a 3-pointer and a pair of three-point plays as Michigan took a 36-16 lead. The Tigers cut the lead to 45-37 before Jordan Morgan scored six consecutive points to restore Michigan's edge. The Wolverines improved to 4-0 all-time against Clemson.
Andre Young led the Tigers with 14 points.
It was just the second time in six games Smotrycz scored in double figures. He made 6 of 7 shots and chipped in six rebounds. Hardaway Jr., son of the former NBA all-star, added 15 points.
Meanwhile, little went right for the Tigers, who missed eight consecutive 3-pointers to end the half. They shot less than 28 percent (8 of 29) and were continually beaten to the basket by the Wolverines.
At least Clemson's baseball team enjoyed its part of the game. Those Tigers were given their College World Series rings before tipoff. That included DH/outfielder-quarterback Kyle Parker, who was benched midway through his final home game by football coach Dabo Swinney, then didn't come out to take questions.
Earlier Tuesday, Parker said he'd stay for Clemson's bowl game.
Still, there were a few boos among the cheers when Parker received his jewelry.