Vanderbilt (54-10) tied the program record for wins in a season while claiming its fourth regional championship, and third in four years.
The Commodores advance to play host to Louisville in a super regional.
Pfeifer (4-0) scattered four hits and handed the ball over to closer Brian Miller, who allowed one run and no hits in four innings for his 16th
Twelve of Vanderbilt’s 13 hits were singles, including five off Georgia Tech starter Buck Farmer (9-5).
Vanderbilt outfielder Mike Yastrzemski, the grandson of Hall of Famer, Carl Yastrzemski, was selected tournament
The Yellow Jackets (37-27) won three consecutive elimination games to force a second championship game against Vanderbilt after blanking the Commodores 5-0 on Sunday.