The Tigers (40-21) snapped a six-game losing streak and will face either Liberty or rival South Carolina in an elimination game Sunday. Clemson avoided its first 0-2 NCAA regional since 1981.
Wilkerson was a big reason why. He put the Tigers ahead with a two-run blast to right in the third inning and added a three-run homer in the fourth that gave Clemson a 6-1 lead.
Shane Kennedy added a solo homer for Clemson. Daniel Gossett (10-4) gave up five hits and two runs in six innings to pick up the victory.
The Billikens (41-21) have lost nine consecutive NCAA Tournament games since reaching the College World Series in 1965.