Facing the Baltimore Orioles on Tuesday night, the Texas Rangers outfielder hit two-run homers in the first, third and seventh innings and added a solo shot in the eighth to tie the major league record. He also doubled in the fifth.
The 18 total bases is a new single-game American League record. His seven RBIs are a career high.
The last player to hit four home runs in a game was Carlos Delgado on Sept. 25, 2003, for Toronto against Tampa Bay.
Two of the 16 players to hit four homers in a game did it before 1900. Hamilton is the sixth AL player to perform the feat.
Hamilton leads the AL with 14 homers and 35 RBIs and is batting .406.