Arkansas (2-4, 1-2 Southeastern Conference) had been blasted by a combined score of 110-10 in its first two league games.
The Tigers (1-4, 0-3) were left at the bottom of the SEC West after a second-half quarterback change failed to provide much of a spark to an offense that committed five turnovers.
Tyler Wilson completed 20 of 27 passes for 216 yards.
Auburn coach Gene Chizik replaced struggling starter Kiehl Frazier with Clint Moseley in the second half, seeking a spark for a sputtering offense. Moseley threw a pair of interceptions in the end zone during the fourth.
NO. 20 MISSISSIPPI STATE 27, KENTUCKY 14
In Lexington, Ky., Tyler Russell passed for two touchdowns and Mississippi State held Kentucky to just 228 yards on offense.
LaDarius Perkins carried 25 times for 110 yards, including a 31-yard score, and Devon Bell kicked field goals of 20 and 37 yards as Mississippi State moved to 5-0 for the first time since 1999. The Bulldogs are 2-0 in conference play.
Freshmen quarterbacks Patrick Towles and Jalen Whitlow both led scoring drives for Kentucky (1-5, 0-3), which lost its fourth in a row.