Sgt. Monica Belser said the incident occurred at Super 8 at 3026 Washington Road at 7:12 a.m.
Witnesses told police they heard gunshots from Room 120, Belser said. No injuries were reported.
The witnesses said they saw two black males leave in a gold-colored Buick with a South Carolina license plate, Belser said.
Anyone with information on the shooting or the whereabouts of the suspects is asked to call the Criminal Investigation Division at (706) 821-1000.