Mike Ayers, of the Georgia Bureau of Investigation, said 40-year-old Harold Randall McDaniels, of Orangeburg, was a suspect in a holdup.
The standoff began around 11:30 a.m. Monday when deputies tried to serve a warrant on McDaniels at the motel.
Ayers said a SWAT team negotiator in the Richmond County Sheriff's Office talked McDaniels into coming out of the room.
Twenty-five to 30 law enforcement officers from McDuffie and Richmond counties had gathered at the motel.
A handful of customers was evacuated from the motel and a nearby Arby's restaurant.