The 19,700-square-foot gourmet supermarket is within South Park shopping center, at 1400 Whiskey Road in Aiken.
The store has generated about 90 jobs, most of which are being filled locally. The grocery also will feature products from growers and producers in the area.
The store is the second Fresh Market in the metro area. In 2009, Fresh Market moved its Augusta store to a new storefront at National Hills shopping center on Washington Road.
The North Carolina-based chain opened its first store locally in 1990 and has 130 stores nationwide.