Green tea lozenge helps dry mouth

Tuesday, July 22, 2014 8:47 PM
Last updated Wednesday, July 23, 2014 12:43 AM
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A lozenge using green tea extract developed at Georgia Regents University appears to work surprisingly well in patients with chronic dry mouth, GRU researchers said.

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Dr. Scott De Rossi (left) and Dr. Stephen Hsu want to see more research on the use of green tea to treat dry mouth.   MICHAEL HOLAHAN/STAFF
MICHAEL HOLAHAN/STAFF
Dr. Scott De Rossi (left) and Dr. Stephen Hsu want to see more research on the use of green tea to treat dry mouth.

In a randomized control trial of the MighTeaFlow lozenge versus a placebo with just the sugar substitute xylitol, the green-tea extract lozenge increased saliva flow nearly fourfold, the study found.

“We were very, very surprised because it is unheard of,” said lozenge inventor Stephen Hsu, a researcher at GRU and the corresponding author on the study. Researchers went looking for similar results in other studies and found “none of them showed something even close to this,” he said.

The study, published online in the journal Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, looked at 60 patients, but Hsu and lead author Dr. Scott De Rossi, chairman of the Department of Oral Health and Diagnostic Sciences in the College of Dental Medicine at GRU, would like to see a bigger study.

For one thing, they would like to get samples of saliva glands before and after the treatment to see if the green tea extracts are actually restoring function to the glands, as they suspect. That was the case in the basic science and animal work Hsu did in looking at powerful chemicals in green tea, most notably epigallocatechin-3-gallate or EGCG.

The lozenge is just one of several commercial products Hsu has helped develop to take advantage of powerful chemicals found in green tea.

“This is true translational research,” De Rossi said.

An estimated 40 percent of people in the U.S. will suffer chronic dry mouth at some point, often from medications they are taking such as in chemotherapy, or from diseases such as diabetes or an autoimmune disease called Sjogren’s syndrome, where the immune system mistakenly attacks the salivary glands.

EGCG and other green tea extracts seem to quiet the autoantigens that provoke the attack, and also seem to increase antioxidant activity, Hsu said.

The number of people estimated to have the problem is probably low because health professionals might not ask and people themselves might not realize they have the problem unless they are asked the right questions, De Rossi said.

“Do you have difficulty swallowing dry foods?” he said. “Are you constantly sipping water throughout the day? Those are sort of habitual things people do and they don’t even realize that maybe there is a problem.”

It is particularly acute among the elderly – an estimated 70 percent of people older than 65 have chronic dry mouth, De Rossi said.

“Mostly due to medications,” he said. “And we know we are becoming an older, sicker population, so we can expect those numbers to rise significantly.”

MORE PRODUCTS

Georgia Regents University researcher Stephen Hsu’s work on the active components of green tea, particularly epigallocatechin-3-gallate or EGCG, led him to create several products that take advantage of its useful properties, such as treating chronic dry mouth and shampoo to fight dandruff and thicken hair. The company Camelllx now distributes these products nationwide and through its Web site, camellix.com. It also sells a version of them in Australia.


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