The South Carolina Highway Patrol says the crash happened at around 8:30 p.m. Wednesday.
Troopers say the driver of a 2009 Honda moped was traveling south, turned left into a private drive and struck a 1991 Nissan truck.
Troopers say the moped driver was not wearing a helmet and was pronounced dead at the scene. The truck driver was not injured.
Authorities are still investigating.