Firefighters were called to a home south of Anderson shortly after 2 p.m. Tuesday to a fire sparked by burning leaves.
They found 62-year-old Robert John Quinnan unresponsive in a burning yard. A neighbor attempted to perform CPR.
Flat Rock-Bowen Fire Chief Michael Hobbs says it took nearly an hour to extinguish the fire, which spread to neighboring property and an empty mobile home.
Quinnan was pronounced dead at the scene.
Anderson County Chief Deputy Coroner Charles Boseman says an autopsy is planned Wednesday.
There were no other injuries.