Coroner Faye Puckett says 31-year-old Henry Allen Timpson and 31-year-old Kelsey Saxon died from injuries in the wreck Saturday night.
The Highway Patrol says two vehicles were driving north on U.S. 221 about five miles north of McCormick when the wreck occurred.
Thirty-three-year-old Chiffon Holloway of Greenwood has been arrested and charged with felony driving under the influence. Holloway was not hurt. It was not clear if Holloway has a lawyer.
Troopers say both victims were wearing seat belts but where thrown from the vehicle.