Portions of Interstate 20 were closed down for nearly half of the day while crews worked to clean up the crashes that left three dead.
According to Georgia State Patrol spokesman Gordy Wright, Vanessa Janise Williams, 21, of Rock Hill, S.C. who is stationed at Fort Gordon, was traveling eastbound in a Chevrolet truck when she struck a deer.
Authorities said her vehicle then traveled through the median and hit a Honda Civic head-on around midnight.
The driver of the Civic, Daniel Sean Williams, was killed.
Vanessa Willams and a 32-year-old passenger in her vehicle have been treated and released.
While westbound traffic was stopped, a Chevrolet 2500 pulling a 30-foot boat hit the rear of a tractor trailer. Wright said the impact from the crash pushed the tractor trailer into the rear of another tractor trailer.
Two of the occupants of the truck were killed. They were identified as Paul Jackson Wood, 56, of Wake Forest, N.C., and Robert Travis Lawson, 23, of Moorehead City, N.C.
The driver of the Chevrolet 2500, Cecil Calvin Holcomb, 19, of Riley, N.C., was airlifted to Medical College of Georgia Hospital.