The massive manhunt began after 6 p.m., when authorities received a call about three people killed on Daytona Road, near South Carolina Highway 39.
Aiken County sheriff's Capt. Charles Barranco said authorities are looking for Ken Meyers, who is 180 pounds and 6 feet tall. Authorities said he was driving a white van that could have ladders on top of it.
Barranco said during a briefing Saturday evening that Meyers is believed to be armed and dangerous and could be headed toward Alabama.
Authorities did not release the identities of the victims or say where they were discovered. Barranco said they were killed by a gun.
Anyone with information about the case can contact the Aiken County Sheriff's Office at (800) 922-9709.