The collision happened at about 3:15 p.m. when a Dodge Ram 1500 traveling west on Columbia Road struck a UPS truck that had stopped behind a tractor trailer just past High Meadows Drive, said Columbia County sheriff's Deputy Jim DiArenzo.
The UPS truck hit the back of the 18-wheeler, which was stopped for a garbage truck turning left into Advanced Disposal, DiArenzo said.
All five people involved in the wreck were sent to Medical College of Georgia hospital with non life-threatening injuries, DiArenzo said.
Thomson residents Corey Anderson, 31; Tiffany Hunley, 18, who is pregnant; and Christine Hunley, 38; were riding in the Dodge truck and not wearing seat belts, he said.
UPS truck driver Adam Cason, 42, and tractor trailer driver Clinton Snellings, 50, with L&L Bulk Inc., also were hospitalized.
Anderson, who was driving the Dodge truck, is being cited with following too closely and other charges are pending, DiArenzo said.