No injuries were reported when the plane came down about 2:45 p.m. Tuesday.
Greenwood County emergency management director Pat Patterson says the plane carrying two people left St. Simons Island, Ga., and was flying to Greenville when it began to experience a problem with the fuel system.
The pilot said he needed to make an emergency landing and tried to get to Greenwood County Airport before landing on the road.
The Highway Patrol is investigating. Jim Peters with the Federal Aviation Administration says the plane belongs to Randall Hollister of Pawley's Island.