Police say the truck knocked 21-year-old Danielle Holly's Nissan Sentra out of control. It was hit by another semi and flipped, landing on its side.
The wreck Sunday night closed all southbound lanes of I-285 near MLK Drive.
Officer Kim Jones with Atlanta police told the Atlanta Journal Constitution that the tractor-trailer's driver, Jack Parsons, was attempting to change lanes.
Parsons was arrested and charged with second degree vehicular homicide and improper lane change.
Holly's husband, whose name was not released, was a passenger in the Nissan. His injuries were not believed to be life-threatening.
Investigators believe the couple lived in Cherokee County.