Capt. John Poole IV of the Dorchester Rural Volunteer Fire Department said the 25,000-square-foot structure was engulfed when firefighters arrived at the scene Sunday afternoon. Crews from nine area fire departments responded.
Firemen were on the scene for four hours and were able to prevent the flames from spreading to several nearby coops.
Dorchester is about 40 miles northwest of Charleston.
There was another chicken fire in Monetta last month, according to Augusta Chronicle archives.
On Jan. 15, about 18,000 chickens died when a chicken house caught fire on Poplar Springs Road, according to Chief Nathan Shuler of the Monetta City Volunteer Fire Department.
Shuler said the chicken house, estimated to be between 400 and 500 feet long, was half destroyed in the blaze, which started around 4:30 p.m.
The New Holland Volunteer Fire Department was the original responder, but quickly called for reinforcements from four other departments, including Monetta City.